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Default Converting many many URL links in RTF file to active links

Thank you very much for reading this.

I have a number of RTF files with bibliographic citations (exported from
RefMan), each citation has a properly formatted link to a URL, which is on a
line by itself preceded by a soft paragraph return.

When I open the RTF in Word, and enter a paragraph return after a URL, the
link becomes "active"€¦.just as it should!

Here is the question€¦some of these RTF documents have 100's of citations,
each with a link that must be made active, so that I can inturn save the
pages as HTML for a web site project.
Is there anyway to search and replace (or some other method) to add a
paragraph return that makes these links active?

A basic search and replace/add paragraph does not do the trick!

Having to click on each URL is way too time consuming€”over 3,200
bibliographic citations and URLs need to made active.

Here is an example€¦

Loyer, X., Heymes, C., and Samuel, J. L.(2008) Constitutive nitric oxide
synthases in the heart from hypertrophy to failure.
Clin.Exp.Pharmacol.Physiol: (35) 483-488.
http://www.ncbi.nlm.nih.gov/pubmed/18307746